A library screening approach identifies naturally occurring RNA sequences for a G-quadruplex binding ligand.
نویسندگان
چکیده
An RNA G-quadruplex library was synthesised and screened against kanamycin A as the ligand. Naturally occurring G-quadruplex forming sequences that differentially bind to kanamycin A were identified and characterized. This provides a simple and effective strategy for identification of potential intracellular G-quadruplex targets for a ligand.
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ورودعنوان ژورنال:
- Chemical communications
دوره 50 10 شماره
صفحات -
تاریخ انتشار 2014